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Medical Physics / Volume 37 / Issue 7 / TISSUE MEASUREMENTS

Med. Phys. 37, 3518 (2010); http://dx.doi.org/10.1118/1.3443563 (9 pages)

Contrast detection in fluid-saturated media with magnetic resonance poroelastography

Phillip R. Perriñez, Adam J. Pattison, Francis E. Kennedy, and Keith D. Paulsen

Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755

John B. Weaver

Department of Radiology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756

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(Received 8 December 2009; accepted 11 May 2010; revised 21 April 2010; published online 15 June 2010)

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Purpose: Recent interest in the poroelastic behavior of tissues has led to the development of magnetic resonance poroelastography (MRPE) as an alternative to single-phase MR elastographic image reconstruction. In addition to the elastic parameters (i.e., Lamé’s constants) commonly associated with magnetic resonance elastography (MRE), MRPE enables estimation of the time-harmonic pore-pressure field induced by external mechanical vibration.
Methods: This study presents numerical simulations that demonstrate the sensitivity of the computed displacement and pore-pressure fields to a priori estimates of the experimentally derived model parameters. In addition, experimental data collected in three poroelastic phantoms are used to assess the quantitative accuracy of MR poroelastographic imaging through comparisons with both quasistatic and dynamic mechanical tests.
Results: The results indicate hydraulic conductivity to be the dominant parameter influencing the deformation behavior of poroelastic media under conditions applied during MRE. MRPE estimation of the matrix shear modulus was bracketed by the values determined from independent quasistatic and dynamic mechanical measurements as expected, whereas the contrast ratios for embedded inclusions were quantitatively similar (10%–15% difference between the reconstructed images and the mechanical tests).
Conclusions: The findings suggest that the addition of hydraulic conductivity and a viscoelastic solid component as parameters in the reconstruction may be warranted.

© 2010 American Association of Physicists in Medicine

Article Outline

  1. INTRODUCTION
  2. METHODS
    1. Forward problem
    2. Inverse problem
    3. Simulated data
    4. Poroelastic phantoms
    5. Mechanical testing
      1. Quasistatic
      2. Dynamic
  3. RESULTS
    1. Numerical simulation
    2. Poroelastic phantoms
    3. Mechanical testing
  4. DISCUSSION
  5. CONCLUSIONS
Digital Object Identifier
http://dx.doi.org/10.1118/1.3443563

KEYWORDS and PACS

Keywords

biological tissues, biomechanics, biomedical MRI, elasticity, phantoms, porosity, shear modulus, MR poroelastography, poroelasticity, mechanical modeling, finite element method

PACS

PUBLICATION DATA

ISSN

0094-2405 (print)  

Publisher

$abstract.society.value is a Member of CrossRef American Association of Physicists in Medicine

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Medical Physics is an official science journal of the AAPM and of the COMP/CCPM/IOMP
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