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Medical Physics / Volume 38 / Issue 6 / 2011 JOINT AAPM/COMP MEETING PROGRAM / IMAGING SCIENTIFIC SESSION: ROOM 211

Med. Phys. 38, 3836 (2011); http://dx.doi.org/10.1118/1.3613444 (1 page)

WE‐G‐211‐05: Advances in X‐Ray Luminescence Computed Tomography: Towards In‐Vivo Imaging of Radioluminescent Nanophosphors

G Pratx, C Carpenter, C Sun, and L Xing

Stanford University School of Medicine, Stanford, CA

  • Abstract
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Purpose: Radioluminescent nanophosphors (RLNPs) show great promise for imaging biological processes in vivo, at the molecular level, and for enhancing the delivery of cytotoxic therapy within the target volume of a radiation treatment. As progress is made towards these goals, there is a need for an imaging modality that can quantitatively measure the distribution of RLNPs in vivo, with high sensitivity and spatial resolution. X‐ray luminescence computed tomography (XLCT) is best placed to meet all these requirements. In this scheme, collimated beams of X‐ray radiation selectively excite RLNPs, producing optical light within a narrowly‐defined volume. Optical measurements of the photons diffusing out of the subject can be interpreted as projective measurements and reconstructed into tomographic images. Methods: As a proof of concept, we built a prototype XLCT system and acquired projective data for near‐IR‐emitting RLNPs embedded in various phantoms. A novel reconstruction scheme that includes a model of light propagation in biological tissue was developed and evaluated on XLCT scans with sparse angular sampling. Results: Imaging in an optically‐diffusive medium shows that imaging performance is not affected by optical scatter; furthermore, the linear response of the reconstructed images suggests that XLCT is capable of quantitative imaging. Reconstruction that combines models of light and X‐ray propagation in tissue was found more accurate for sparsely‐sampled datasets. Conclusion: Based on phantom experiments, we found XLCT to be a feasible approach for imaging RLNPs tomographically. As we advance towards our goal of imaging RLNPs in live animals, we are designing and building a new imaging set‐up with improved X‐ray collimation and light collection efficiency.

© 2011 American Association of Physicists in Medicine

Digital Object Identifier
http://dx.doi.org/10.1118/1.3613444

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0094-2405 (print)  

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$abstract.society.value is a Member of CrossRef American Association of Physicists in Medicine

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Medical Physics is an official science journal of the AAPM and of the COMP/CCPM/IOMP
William R. Hendee, Editor
Departments of Radiology, Radiation Oncology, Biophysics, Community and Public Health, Medical College of Wisconsin
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College Park, Maryland 20740
301-209-3352

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